Howard E, Olton D S, Johnson C T
Dev Psychobiol. 1976 May;9(3):217-21. doi: 10.1002/dev.420090305.
Fond deprivation was produced in infant rats, from 2 to 20 days of age, by a procedure designed to minimize reduction in maternal care. Body weights in the deprived animals were 60% of control weights at 7 days, 65% at 20 days, and, after ad lib feeding, 89% at 4 months. No change was observed in the rate of acquistion of a conditioned active avoidance response in the food-deprived rats when compared with their littermate controls when tested as adults. No lasting reduction in cerebral desoxynucleic acid (DNA) was observed despote a 9% reduction in cerebellar DNA.
通过一种旨在尽量减少母性照料减少的程序,对出生2至20天的幼鼠造成母爱剥夺。在7天时,被剥夺组动物的体重为对照组体重的60%,20天时为65%,自由采食后,4个月时为89%。当成年后进行测试时,与同窝对照相比,食物剥夺组大鼠的条件性主动回避反应习得率没有变化。尽管小脑DNA减少了9%,但未观察到大脑脱氧核糖核酸(DNA)有持续减少。