Methfessel H D
Zentralbl Gynakol. 1978;100(6):381-7.
The effect of phentolamine and pholedrin sulfate on the female urethra was studied for electronical measurement of the urethral pressure profile. In 9 healthy women the administered of phentolamine (0,15 mg/kg body weight) resulted in a significant reduction of the maximal urethral closure pressure, the functional length of the urethra and the total areas under pressure profile. Following the injection of pholedrin sulfate (0,3 mg/kg body weight) a marked increase of the maximal urethral closure pressure and the total area under pressure profile was observed. The functional urethral length remained unchanged. New concepts of medicamentous influence of the urethral closure pressure were discussed.
为了通过电子测量尿道压力轮廓来研究酚妥拉明和硫酸麻黄碱对女性尿道的作用。对9名健康女性给予酚妥拉明（0.15mg/kg体重）后，最大尿道闭合压、尿道功能长度和压力轮廓下的总面积显著降低。注射硫酸麻黄碱（0.3mg/kg体重）后，观察到最大尿道闭合压和压力轮廓下的总面积显著增加。尿道功能长度保持不变。讨论了药物对尿道闭合压影响的新概念。
