Iosif S, Forman A, Jeppsson S, Mellqvist P, Rannevik G, Ulmsten U
Zentralbl Gynakol. 1981;103(22):1344-7.
The urethral pressure profile was recorded, at rest and under stress, from six women in fertile age, before and at the end of an eight-week treatment during which the probands received daily doses of 600 mg of Danazol. Only moderate decrease in maximum urethral pressure was established, at rest, though oestrogen production was markedly reduced. Reduction in transmission of intra-abdominal pressure to the urethra was registered under stress, but urethral closure pressure remained positive in all subjects. Bladder pressure and functional length of the urethra were almost unaffected. Danazol treatment does not seem to jeopardize maintenance of urinary continence in young females.
对六名育龄期女性在静息状态和应激状态下记录尿道压力曲线，记录时间分别为在接受为期八周的治疗前和治疗结束时，在此期间，先证者每日服用600毫克达那唑。尽管雌激素分泌明显减少，但仅发现静息状态下最大尿道压力有中度下降。在应激状态下记录到腹内压向尿道的传递减少，但所有受试者的尿道闭合压仍为正值。膀胱压力和尿道功能长度几乎未受影响。达那唑治疗似乎不会危及年轻女性尿失禁的维持。
