The effect of danazol on the human female urethra.

The urethral pressure profile was recorded, at rest and under stress, from six women in fertile age, before and at the end of an eight-week treatment during which the probands received daily doses of 600 mg of Danazol. Only moderate decrease in maximum urethral pressure was established, at rest, though oestrogen production was markedly reduced. Reduction in transmission of intra-abdominal pressure to the urethra was registered under stress, but urethral closure pressure remained positive in all subjects. Bladder pressure and functional length of the urethra were almost unaffected. Danazol treatment does not seem to jeopardize maintenance of urinary continence in young females.