Ito H, Kurihara S, Nishimura C
Obstet Gynecol. 1978 Apr;51(4):468-71. doi: 10.1097/00006250-197804000-00017.
Serum levels of carcinoembryonic antigen (CEA) were measured by a radioimmunoassay technique. The mean CEA level for 80 controls was 2.03 ng/ml with a standard deviation of 0.49 ng/ml. Hence, the upper limit of normal for serum CEA levels was considered to be 3.01 ng/ml, ie, two standard deviations above the mean. Serum CEA levels were measured in 86 patients with cervical squamous cell carcinoma, Stages 0 through IV. Thirty-five of the 74 patients with invasive cervical carcinoma were CEA-positive (serum levels above normal); patients with cervical dysplasia or carcinoma in situ were all CEA-negative. Study of the distribution of these patients together with the extent of their disease leads to the following conclusions: a) determination of serum CEA levels cannot serve as a test for the early diagnosis of cervical cancer or precancerous lesions; b) in patients with clinical Stage I or II cervical cancer, an elevated serum CEA level indicates a greater likelihood of parametrial invasion or lymph node metastasis; c) in patients with treated carcinoma of the cervix, continued normal levels of serum CEA affirm continued absence of the disease, whereas development of an elevated level is highly suspicious of occult residual or recurrent cancer. The authors urge periodic determinations of serum CEA levels in patients with treated cervical cancer.
采用放射免疫测定技术检测血清癌胚抗原（CEA）水平。80名对照者的平均CEA水平为2.03 ng/ml，标准差为0.49 ng/ml。因此，血清CEA水平的正常上限被认为是3.01 ng/ml，即高于平均值两个标准差。对86例0至IV期宫颈鳞状细胞癌患者进行了血清CEA水平检测。74例浸润性宫颈癌患者中有35例CEA呈阳性（血清水平高于正常）；宫颈发育异常或原位癌患者均为CEA阴性。对这些患者的分布及其疾病程度进行研究得出以下结论：a）血清CEA水平的测定不能作为宫颈癌或癌前病变早期诊断的检测方法；b）对于临床I期或II期宫颈癌患者，血清CEA水平升高表明宫旁组织浸润或淋巴结转移的可能性更大；c）对于接受过宫颈癌治疗的患者，血清CEA水平持续正常表明疾病持续不存在，而水平升高则高度怀疑隐匿性残留或复发性癌症。作者敦促对接受过宫颈癌治疗的患者定期测定血清CEA水平。
