Starzl T E, Watanabe K, Porter K A, Putnam C W
Lancet. 1976 Apr 17;1(7964):821-5. doi: 10.1016/s0140-6736(76)90477-3.
Insulin, glucagon, and insulin/glucagon mixtures have been infused for four days into the left portal vein of dogs after portacaval shunt. In the left but not in the right liver lobes, insulin alone reduced atrophy, preserved hepatocyte ultrastructure, and trebled cell renewal. Glucagon alone had no effect. In small doses, glucagon did not potentiate the action of insulin and in large doses it may have reduced the insulin benefit. These studies explain the development of the previously mysterious Eck fistula syndrome, provide clues about in-vivo cell growth control by hormones, and suggests new lines of inquiry about the pathogenesis and/or treatment of several human disease processes.
在门腔分流术后，已将胰岛素、胰高血糖素以及胰岛素/胰高血糖素混合物注入狗的左门静脉四天。在左肝叶而非右肝叶中，单独使用胰岛素可减少萎缩、保留肝细胞超微结构并使细胞更新增加两倍。单独使用胰高血糖素则无作用。小剂量时，胰高血糖素不会增强胰岛素的作用，而大剂量时它可能会降低胰岛素的益处。这些研究解释了先前神秘的埃克瘘综合征的发展，提供了关于激素对体内细胞生长控制的线索，并为几种人类疾病过程的发病机制和/或治疗提出了新的研究方向。
