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门静脉内注射胰岛素可保护犬门腔静脉分流术所致的肝损伤。

Intraportal insulin protects from the liver injury of portacaval shunt in dogs.

作者信息

Starzl T E, Porter K A, Putnam C W

出版信息

Lancet. 1975 Dec 20;2(7947):1241-2. doi: 10.1016/s0140-6736(75)92076-0.

DOI:10.1016/s0140-6736(75)92076-0
PMID:53727
Abstract

4 days after portacaval shunt, the livers of normal dogs had pronounced atrophy and other structural abnormalities. These changes were greatly reduced in the left liver lobes, but not in the right, by a constant infusion to the left portal vein of insulin in non-hypoglycaemic doses. These experimental findings should have implications in clinical medicine.

摘要

门腔分流术后4天,正常犬的肝脏出现明显萎缩及其他结构异常。通过以非低血糖剂量持续向左门静脉输注胰岛素,左肝叶的这些变化大为减轻,但右肝叶未减轻。这些实验结果应会对临床医学产生影响。

相似文献

1
Intraportal insulin protects from the liver injury of portacaval shunt in dogs.门静脉内注射胰岛素可保护犬门腔静脉分流术所致的肝损伤。
Lancet. 1975 Dec 20;2(7947):1241-2. doi: 10.1016/s0140-6736(75)92076-0.
2
Effects of insulin, glucagon, and insuling/glucagon infusions on liver morphology and cell division after complete portacaval shunt in dogs.胰岛素、胰高血糖素以及胰岛素/胰高血糖素输注对犬完全门腔静脉分流术后肝脏形态及细胞分裂的影响。
Lancet. 1976 Apr 17;1(7964):821-5. doi: 10.1016/s0140-6736(76)90477-3.
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Growth-stimulating factor in regenerating canine liver.犬肝脏再生中的生长刺激因子。
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The influence of portal blood upon lipid metabolism in normal and diabetic dogs and baboons.门静脉血对正常及糖尿病犬和狒狒脂质代谢的影响。
Surg Gynecol Obstet. 1975 Mar;140(3):381- 96.
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The mechanism of postshunt liver failure.分流术后肝衰竭的机制。
Surgery. 1977 Nov;82(5):738-49.
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Effects of portacaval shunt, transposition, and dimethylnitrosamine-induced chronic liver injury on pancreatic hormones and amino acids in dog.
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[Intrahepatic portal arterialization associated with portacaval shunt: a preliminary experimental report].
Zhonghua Wai Ke Za Zhi. 1983 Apr;21(4):211-6.
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Hepatic insufficiency after portacaval shunting is prevented by prior intraportal pancreatic islet autotransplantation.
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Portal hepatotrophic factors, diabetes mellitus and acute liver atrophy, hypertrophy and regeneration.门脉性肝营养因子、糖尿病与急性肝萎缩、肥大及再生
Surg Gynecol Obstet. 1975 Dec;141(6):843-58.
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Temporary beneficial effect of arterialization of the liver in cirrhotic dogs with a portacaval shunt. A preliminary report.
Eur Surg Res. 1982 Sep-Oct;14(5):333-43. doi: 10.1159/000128306.

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Insights on augmenter of liver regeneration cloning and function.肝脏再生增强因子的克隆与功能研究进展
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Portacaval shunt causes apoptosis and liver atrophy in rats despite increases in endogenous levels of major hepatic growth factors.门腔分流术可导致大鼠发生细胞凋亡和肝脏萎缩,尽管肝脏主要生长因子的内源性水平有所升高。
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