Starzl T E, Jones A F, Terblanche J, Usui S, Porter K A, Mazzoni G
Lancet. 1979 Jan 20;1(8108):127-30. doi: 10.1016/s0140-6736(79)90519-1.
Extracts from dog livers which had been regenerating for 24, 48, and 72 h after hepatectomy were infused for 6 h into the left portal vein of animals which had fresh portacaval shunts (Eck fistula) and which were killed 2 and 3 days later. The brief exposure to the 48-h and especially the 72-h regenerating liver extracts induced a delayed proliferative response predominantly in the left liver lobes, with a slight spillover effect to the right liver lobes but none to the kidney. The response reached its peak 3 days later. In the left but not the right liver lobes, both the 48-h and the 72-h regenerating liver extract reversed the atrophy ordinarily caused by Eck fistula in 3 days and partly prevented the ultrastructural hepatocyte deterioration characteristic of Eck fistula. The active liver extracts apparently contained a growth-control factor or factors which is (are) not insulin or glucagon.
将肝切除术后分别再生24小时、48小时和72小时的犬肝脏提取物，注入到患有新鲜门腔分流术（埃克瘘）的动物的左门静脉中，并持续6小时，这些动物在2天和3天后被处死。短暂接触48小时尤其是72小时再生肝脏提取物后，主要在左肝叶诱导了延迟性增殖反应，对右肝叶有轻微的溢出效应，但对肾脏无影响。该反应在3天后达到峰值。在左肝叶而非右肝叶中，48小时和72小时再生肝脏提取物在3天内逆转了通常由埃克瘘引起的萎缩，并部分预防了埃克瘘特征性的超微结构肝细胞恶化。活性肝脏提取物显然含有一种或多种生长控制因子，这些因子不是胰岛素或胰高血糖素。
