Prokopenko L G, Konoplia A I
Zh Mikrobiol Epidemiol Immunobiol. 1978 Feb(2):36-40.
The authors studied the influence of various doses of thiamine on the formation of immune response in the animals with toxic affection of the liver. As revealed, thiamine in a dose of 400 microgram per kg of body weight inhibited the formation of the immune response in healthy rats, but failed to influence this process in the animals with toxic affection of the liver. Thiamine in a dose of 100 microgram per 100 g of body weight stimulated the formation of the immune response in healthy rats and in those poisoned with carbon tetrachloride. The simulating effect of thiamine was more pronounced in poisoned than in healthy rats. The blood serum of rats poisoned with carbon tetrachloride enhanced the immunostimulating action of thiamine.
作者研究了不同剂量硫胺素对肝脏中毒性损伤动物免疫反应形成的影响。结果表明，每千克体重400微克剂量的硫胺素抑制健康大鼠免疫反应的形成，但对肝脏中毒性损伤的动物此过程无影响。每100克体重100微克剂量的硫胺素刺激健康大鼠以及四氯化碳中毒大鼠免疫反应的形成。硫胺素对中毒大鼠的刺激作用比对健康大鼠更明显。四氯化碳中毒大鼠的血清增强了硫胺素的免疫刺激作用。
