Prokopenko L G, Kedrovskaia N N
Zh Mikrobiol Epidemiol Immunobiol. 1976 Jun(6):57-62.
The work was aimed at the study of possibilities of passive transfer of the immunostimulating effect (with the aid of blood serum) observed in various pathological conditions of the liver. Investigations were carried out on rabbits poisoned with carbon tetrachloride (primary serum donors), healthy rabbits (primary recipients and secondary donors of the serum), and healthy rabbits (secondary serum recipients). Crude and heated (for 30 min at 56 degrees C) sera of rabbits poisoned with carbon tetrachloride stimulated production of antibodies induced with the antigen in the intact animals. Under the effect of trasilol, a polyvalent proteinase inhibitor, the sera of rabbits poisoned with carbon tetrachloride lost their immunostimulating properties. The sera of rabbits given injections of the sera obtained from the poisoned animals produced an immunostimulating action which failed to disappear under the effect of trasilol.
这项工作旨在研究在肝脏的各种病理状况下观察到的免疫刺激作用（借助血清）被动转移的可能性。对用四氯化碳中毒的兔子（初代血清供体）、健康兔子（血清的初代受体和二代供体）以及健康兔子（二代血清受体）进行了研究。用四氯化碳中毒的兔子的粗制血清和加热（在56摄氏度下30分钟）血清刺激了未受损伤动物体内由抗原诱导产生的抗体生成。在抑肽酶（一种多价蛋白酶抑制剂）的作用下，用四氯化碳中毒的兔子的血清失去了它们的免疫刺激特性。注射从中毒动物获得的血清的兔子的血清产生了一种免疫刺激作用，该作用在抑肽酶的作用下并未消失。
