Uspenskiĭ A E
Farmakol Toksikol. 1978 Jun-Aug;41(4):418-20.
Sodium salt of 3,4-dihydroxyphenyl-alpha-hydroxypropionic acid inhibits exploratory behavior and induces hypothermia in mice. The compound enhances central effects of L-DOPA, such as: gross excitation in group, fighting behavior, anticataleptogenic action and hyperthermic effect. The L-DOPA central effects are mitigated by pyridoxal phosphate. The 3,4-dihydroxyphenyl-alpha-hydroxypropionic acid sodium salt abolishes the protective action of pyridoxal phosphate. In vitro this salt inhibits DOPA-decarboxylase. It is suggested that the compound under discussion is a competitive antagonist of L-DOPA, when the latter is involved in reactions with pyridoxal phosphate.
3,4-二羟基苯基-α-羟基丙酸钠盐可抑制小鼠的探究行为并使其体温过低。该化合物增强了左旋多巴的中枢作用，例如：群体中的总体兴奋、打斗行为、抗僵住作用和体温升高效应。左旋多巴的中枢作用可被磷酸吡哆醛减轻。3,4-二羟基苯基-α-羟基丙酸钠盐消除了磷酸吡哆醛的保护作用。在体外，这种盐可抑制多巴脱羧酶。有人认为，当左旋多巴参与与磷酸吡哆醛的反应时，所讨论的化合物是左旋多巴的竞争性拮抗剂。
