Uspenskiĭ A E, Dabagov N S, Skoldinov A P
Biull Eksp Biol Med. 1978 Oct;86(10):444-7.
D,L-beta-(3,4-dihydroxyphenyl)lactic acid (I), D,L-beta-(5-hydroxyindolyl-3)lactic acid (II), and L-alpha-methyl-DOPA (III) inhibited the aromatic amino acid decarboxylase (AAAD) competitively. In difference from the compound III, I and II were not AAAD substrates. Compound II selectively suppressed decarboxylation of L-5-hydroxytryptophane. Compounds I and III potentiated the excitation caused in mice by L-DOPA and failed to influence the excitation due to L-5-hudroxytryptophane (L-5-HTP). Compound II attenuated the excitation caused by L-DOPA and L-5-HTP. Pyridoxine hydrochloride and pyridoxalphosphate attenated the excitation caused by L-DOPA and L-5-HTP. Compounds I and III eliminated this action of vitamins B6.
D，L-β-（3,4-二羟基苯基）乳酸（I）、D，L-β-（5-羟基吲哚-3）乳酸（II）和L-α-甲基多巴（III）竞争性抑制芳香族氨基酸脱羧酶（AAAD）。与化合物III不同，I和II不是AAAD的底物。化合物II选择性抑制L-5-羟色氨酸的脱羧作用。化合物I和III增强了左旋多巴对小鼠的兴奋作用，且不影响L-5-羟色氨酸（L-5-HTP）引起的兴奋。化合物II减弱了左旋多巴和L-5-HTP引起的兴奋。盐酸吡哆醇和磷酸吡哆醛减弱了左旋多巴和L-5-HTP引起的兴奋。化合物I和III消除了维生素B6的这种作用。
