Hurtgen J P, Whitmore H L
J Am Vet Med Assoc. 1978 Jul 1;173(1):97-100.
In 10 mares, lysis of the corpus luteum was induced by endometrial biopsy and culture on day 4 after estrus, as evidenced by a sharp decline in serum progesterone concentration and a shortened interestrous interval. Estrus following the manipulations was prolonged. Endometrial biopsy and culture on days 1 and 3 after estrus or manually dilating the cervix on day 4 after estrus also decreased the serum progesterone concentration (within 24--48 hr after manipulation), shortened diestrus, and prolonged the subsequent estrus. In a 2nd experiment, endometrial biopsy on day 4 after estrus shortened the estrous cycle and diestrous period and prolonged the subsequent estrus. It was postulated that these manipulations stimulated corpus luteum regression, followed by estrus and ovulation in the mare.
在10匹母马中，发情后第4天通过子宫内膜活检和培养诱导黄体溶解，血清孕酮浓度急剧下降和发情间期缩短证明了这一点。操作后的发情期延长。发情后第1天和第3天进行子宫内膜活检和培养，或发情后第4天手动扩张子宫颈，也会降低血清孕酮浓度（操作后24 - 48小时内），缩短间情期，并延长随后的发情期。在第二个实验中，发情后第4天进行子宫内膜活检缩短了发情周期和间情期，并延长了随后的发情期。据推测，这些操作刺激了母马黄体退化，随后发情和排卵。
