AKR小鼠中IgE抗体产生的增强。

Enhancement of IgE antibody production in AKR mice.

作者信息

Watanabe N, Ovary Z

出版信息

Int Arch Allergy Appl Immunol. 1978;57(6):554-9. doi: 10.1159/000232152.

Abstract

When dinitrophenylated keyhole limpet hemocyanin (DNP-KLH) primed AKR mice were injected with dinitrophenylated Nippostrongylus brasiliensis extract (DNP-Nb), an enhancement of IgE antibody production was obtained by nematode parasite, N. brasiliensis, infection or by Nb antigen injection 2 weeks before DNP-Nb injection. A preferential enhancement of IgE production was observed in infected mice compared with Nb-injected mice. Anti-hapten IgE antibody response was suppressed in AKR mice after appropriate immunization. No suppression of IgE response was observed after whole body irradiation (180-540 R) at an early stage of immunization. High and persistent IgE response was observed in (AKR X DBA/1)F1 mice of both sexes, therefore, the suppressive effect on IgE response in AKR mice was inherited as an autosomal recessive trait. The similarity of IgE class specific suppression in AKR and SJL mice is discussed.

摘要

用二硝基苯基化的钥孔戚血蓝蛋白（DNP-KLH）致敏AKR小鼠后，再注射二硝基苯基化的巴西日圆线虫提取物（DNP-Nb），在注射DNP-Nb前2周，通过感染线虫寄生虫巴西日圆线虫或注射Nb抗原，可增强IgE抗体的产生。与注射Nb的小鼠相比，在感染小鼠中观察到IgE产生的优先增强。适当免疫后，AKR小鼠的抗半抗原IgE抗体反应受到抑制。在免疫早期进行全身照射（180 - 540拉德）后，未观察到IgE反应的抑制。在雌雄两性的（AKR×DBA/1）F1小鼠中均观察到高且持续的IgE反应，因此，对AKR小鼠IgE反应的抑制作用作为常染色体隐性性状遗传。讨论了AKR和SJL小鼠中IgE类特异性抑制的相似性。