Aĭtmagambetova B Z, Vygodskaia A L, Korogodina Iu V, Petrosian E P, Iarmonenko S P
Kosm Biol Aviakosm Med. 1978 Jul-Aug;12(4):50-4.
Studies of 5-day mice F1 (CBA X C57Bl) demonstrated that an exposure of animals to acute hypoxia (5% O2--95% N2) during their irradiation produced a different effect on the spleen and the growing cerebellar cortex. In these circumstances lesions of well oxygenated spleen tissues were noticeably reduced, whereas cerebellar cortex cells characterized by a low oxygen tension and a high tolerance to anoxia remained essentially unprotected. The findings are discussed in the light of adaptation concepts postulating that oxygen tension in cells is regulated, depending on the level of its uptake which in turn is determined by the relative oxygen content in the surrounding medium.
对5日龄F1代（CBA×C57Bl）小鼠的研究表明，在辐照期间让动物暴露于急性低氧环境（5%氧气 - 95%氮气）中，会对脾脏和正在发育的小脑皮质产生不同影响。在这种情况下，充分氧合的脾脏组织损伤明显减少，而以低氧张力和高耐缺氧性为特征的小脑皮质细胞基本上未得到保护。根据适应概念对这些发现进行了讨论，该概念假定细胞中的氧张力是根据其摄取水平进行调节的，而摄取水平又由周围介质中的相对氧含量决定。
