Gross S J, Kosmetatos N, Grimes C T, Williams M L
Am J Dis Child. 1978 Aug;132(8):753-6. doi: 10.1001/archpedi.1978.02120330025005.
One hundred eighteen infants with birth weights of 2,000 g or less were evaluated for growth and development at approximately 5 years of age. Review of neonatal data indicated that head circumference less than the tenth percentile at birth and abnormal neurological examination in the newborn period were important predictors of outcome. Both of these factors were associated with poor growth, later microcephaly, and neurological deficit. In addition, neonatal microcephaly was substantially related to poor intellectual attainment. Other associations were seen between microcephaly at birth and intrauterine growth retardation, low Apgar score, and low socioeconomic status, factors that also correlated with poor outcome.
对118名出生体重2000克及以下的婴儿在约5岁时进行了生长发育评估。新生儿数据回顾表明，出生时头围小于第十百分位数以及新生儿期神经检查异常是预后的重要预测因素。这两个因素均与生长发育不良、后期小头畸形和神经功能缺损有关。此外，新生儿小头畸形与智力发育不良密切相关。出生时小头畸形与宫内生长迟缓、阿氏评分低和社会经济地位低之间也存在其他关联，这些因素也与不良预后相关。
