Amin H, Singhal N, Sauve R S
Department of Pediatrics, University of Calgary, Alberta, Canada.
Acta Paediatr. 1997 Mar;86(3):306-14. doi: 10.1111/j.1651-2227.1997.tb08895.x.
The impact of intrauterine growth restriction (IUGR) in very low birthweight preterm infants weighing < or = 1250 g was determined by comparing longitudinal growth and neurodevelopmental outcome to an adjusted age of 36 months in 52 intrauterine growth restricted children, with 55 birthweight-matched and 56 gestational age-matched children. None of these children had chromosomal anomalies, congenital infections, or major congenital malformations. Gestational ages of intrauterine growth restricted, birthweight- and gestational age-matched infants were 30 (+/-3), 26 (+/-2), 29 (+/-2) weeks: birthweights were 842 (+/-232), 872 (+/-201) and 1094 (+/-142) g, respectively. Intrauterine growth restricted children had fewer complications during initial hospitalization (p < 0.05), and had lower weights and head circumferences at follow-up (p < 0.05). No significant differences were present in major neurodevelopmental disabilities between the intrauterine growth restricted and two comparison groups. Persistence of microcephaly was associated with adverse neurodevelopmental outcome.
通过比较52名宫内生长受限儿童与55名出生体重匹配儿童及56名胎龄匹配儿童至36个月校正年龄时的纵向生长情况和神经发育结局，确定了宫内生长受限（IUGR）对出生体重≤1250g的极低出生体重早产儿的影响。这些儿童均无染色体异常、先天性感染或重大先天性畸形。宫内生长受限、出生体重和胎龄匹配婴儿的胎龄分别为30（±3）、26（±2）、29（±2）周；出生体重分别为842（±232）、872（±201）和1094（±142）g。宫内生长受限儿童在初次住院期间并发症较少（p<0.05），随访时体重和头围较低（p<0.05）。宫内生长受限组与两个对照组在主要神经发育障碍方面无显著差异。小头畸形的持续存在与不良神经发育结局相关。
