普萘洛尔、MJ 1999和奎尼丁的某些心血管特性与其对高血压动物作用的比较。
A comparison of some cardiovascular properties of propranolol, MJ 1999 and quinidine in relation to their effects in hypertensive animals.
作者信息
Farmer J B, Levy G P
出版信息
Br J Pharmacol. 1968 Sep;34(1):116-26. doi: 10.1111/j.1476-5381.1968.tb07955.x.
Abstract
- A comparison of some cardiovascular effects of propranolol, MJ 1999 and quinidine has been made in rats and dogs.2. After intravenous, subcutaneous or oral administration to rats and dogs, propranolol was found to be 2-4 times more potent than MJ 1999 in blocking the chronotropic and vasodepressor responses to intravenously administered isoprenaline.3. Propranolol and quinidine affected the e.c.g. of rats and dogs in a similar manner.4. At dose-levels causing effective blockade of beta-receptors propranolol and MJ 1999 had no hypotensive effect after short- or long-term administration to conscious hypertensive rats and dogs.5. At very high dose-levels propranolol and quinidine, but not MJ 1999, lowered blood pressure in the hypertensive rat. This effect of propranolol is probably related to one or more of the properties that propranolol and quinidine have in common rather than to a blockade of beta-receptors.6. The possible relevance of these results to the use of propranolol as a hypotensive agent in man is discussed.
摘要
已在大鼠和犬中比较了普萘洛尔、MJ 1999和奎尼丁的一些心血管效应。
对大鼠和犬静脉内、皮下或口服给药后，发现普萘洛尔在阻断静脉注射异丙肾上腺素引起的变时性和血管减压反应方面比MJ 1999强2至4倍。
普萘洛尔和奎尼丁对大鼠和犬心电图的影响方式相似。
在对清醒的高血压大鼠和犬短期或长期给药后，在能有效阻断β受体的剂量水平下，普萘洛尔和MJ 1999没有降压作用。
在非常高的剂量水平下，普萘洛尔和奎尼丁可降低高血压大鼠的血压，但MJ 1999不行。普萘洛尔的这种作用可能与其和奎尼丁共有的一种或多种特性有关，而不是与β受体阻断有关。
讨论了这些结果与普萘洛尔在人类中作为降压药使用的可能相关性。
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