Kalemba K
Med Pr. 1983;34(3):211-7.
187 workers exposed to vinyl chloride (VC) were examined. The control group consisted of workers of the same plant but not exposed to vinyl chloride. In all workers biochemical liver function tests were performed. The results showed no damaging influence of VC on the liver cells membrane. A slight increase of the aminotransferases (ALAT, AspAT) activity was noticed only in alcohol drinking persons. The most important changes of the glutamyltranspeptidase activity were found. Increased activity of this enzyme was noticed in 84 persons. The results suggest the induction of the glutamyltranspeptidase (GGTP) activity by VC after exclusion of the effects of other agents like cholestase, barbiturates, ethyl alcohol, as well as the effects of carcinogenesis.
对187名接触氯乙烯（VC）的工人进行了检查。对照组由同一工厂但未接触氯乙烯的工人组成。对所有工人都进行了肝脏生化功能测试。结果显示VC对肝细胞细胞膜没有损害作用。仅在饮酒者中发现氨基转移酶（丙氨酸转氨酶、天冬氨酸转氨酶）活性略有增加。发现谷氨酰转肽酶活性有最重要的变化。84人出现该酶活性增加。结果表明，在排除胆汁淤积酶、巴比妥类药物、乙醇等其他因素的影响以及致癌作用的影响后，VC可诱导谷氨酰转肽酶（GGTP）活性。
