Petrov R V, Khaitov R M, Ataullakhanov R I, Sidorovich I G
Zh Mikrobiol Epidemiol Immunobiol. 1978 Jul(7):56-61.
As revealed by the method of cultivation of bone marrow and spleen cells, separated by nucleopore membrane, in two-chamber bottles, the bone marrow cells were capable of producing humoral factor stimulating antibody genesis by the spleen cells. A direct contact of the bone marrow cells with the actively proliferating antigen-stimulated cells of the spleen led to production of a spleen humoral factor suppressing the antibody genesis by the spleen cells. The suppressive action of the bone marrow cells on the antibody genesis in the culture of the spleen cells was mediated through the suppression of the spleen cells proliferation; proliferation of the bone marrow cells is enhanced.
通过在双室瓶中用核孔膜分离培养骨髓细胞和脾细胞的方法发现，骨髓细胞能够产生刺激脾细胞产生抗体的体液因子。骨髓细胞与脾中活跃增殖的抗原刺激细胞直接接触会导致产生抑制脾细胞抗体产生的脾体液因子。骨髓细胞对脾细胞培养中抗体产生的抑制作用是通过抑制脾细胞增殖介导的；骨髓细胞的增殖增强。
