[γ-羟基丁酸锂对大鼠下丘脑多肽及去甲肾上腺素含量的影响]
[Effect of lithium oxybutyrate on the polypeptide and noradrenaline content in the rat hypothalamus].
作者信息
Arefolov V A, Iavorskiĭ A N, Malikova L A
出版信息
Farmakol Toksikol. 1979 May-Jun;42(3):208-12.
PMID:446697
Abstract
It was established that single administration to rats of 200 mg/kg of lithium hydroxybutyrate releases noradrenalin from the terminals of hypothalamus adrenergic fibers and increases output of polypeptides in the neurons of supraoptic and paraventricular nuclei of the hypothalamus. After repeated administration of the drug (200 mg/kg) once a day over 6 days) the nuclei showed depressed output of polypeptides.
摘要
已确定，给大鼠单次注射200mg/kg的羟基丁酸锂会促使去甲肾上腺素从下丘脑肾上腺素能纤维的末端释放出来，并增加下丘脑视上核和室旁核神经元中多肽的输出。在每天一次重复给药（200mg/kg，持续6天）后，这些核团中多肽的输出显示下降。
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