Hill S Y
Pharmacol Biochem Behav. 1978 Jul;9(1):107-10. doi: 10.1016/0091-3057(78)90019-9.
Two inbred strains of Tryon rats were tested for consumption of morphine (0.5 mg/ml) and alcohol (10% w/v) solutions in both free and forced situations. Statistically significant differences in intake by strain were found both for morphine and alcohol. The Tryon S3 strain consumed significantly more morphine than the S1 strain in two of the four phases of the experiment. The Tryon S1 strain consumed significantly more alcohol than the S3 in two of the four phases. Factors affecting consumption of drug solutions including sex and activity level were assessed using analysis of covariance. Strain differences were apparent even when these factors were removed from the analyses. These results are discussed in relation to previous reports suggesting a common addiction liability for both morphine and alcohol in inbred strains of animals.
对两种近交系的特赖恩大鼠在自由和强制情况下对吗啡（0.5毫克/毫升）溶液和酒精（10%重量/体积）溶液的消耗量进行了测试。在吗啡和酒精的摄入量上，均发现品系间存在统计学上的显著差异。在实验的四个阶段中的两个阶段，特赖恩S3品系消耗的吗啡比S1品系显著更多。在四个阶段中的两个阶段，特赖恩S1品系消耗的酒精比S3品系显著更多。使用协方差分析评估了包括性别和活动水平在内的影响药物溶液消耗量的因素。即使从分析中去除这些因素，品系差异仍然明显。结合之前的报告讨论了这些结果，之前的报告表明在动物近交系中吗啡和酒精存在共同的成瘾倾向。
