Loeser E A, Hodges M, Gliedman J, Stanley T H, Johansen R K, Yonetani D
Anesth Analg. 1978 Sep-Oct;57(5):577-9. doi: 10.1213/00000539-197809000-00013.
Histologic sections of dog tracheas were taken from 20 dogs anesthetized and intubated for 5 to 7 hours with high-pressure, low-volume Shiley or low-pressure, high-volume Lanz endo-tracheal tubes. Microscopic examination and measurement showed that while the high-pressure, low-volume cuff produced deeper average mucosal erosion, the large-volume, low-pressure cuff resulted in significantly greater lengths of tracheal mucosa-cuff erosion. Maximal depth of penetration throught the basement membrane was similar in both groups. Grooves in the mucosa were seen in 50% of the high-volume-cuff trachea sections but none of the low-volume-cuff tracheal sections. These findings demonstrate that low-pressure, high-volume endotracheal tube cuffs produce different but significant tracheal damage after short-term intubation when compared to high-pressure, low-volume cuffs.
从20只接受麻醉并插管5至7小时的狗身上获取气管组织切片，这些狗使用的是高压、低容量的Shiley气管内导管或低压、大容量的Lanz气管内导管。显微镜检查和测量显示，虽然高压、低容量的套囊造成的平均黏膜侵蚀更深，但大容量、低压的套囊导致气管黏膜 - 套囊侵蚀的长度明显更长。两组穿过基底膜的最大穿透深度相似。在50%的大容量套囊气管切片中可见黏膜沟槽，但小容量套囊气管切片中均未见到。这些发现表明，与高压、低容量套囊相比，低压、大容量气管内导管套囊在短期插管后会产生不同但显著的气管损伤。
