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化学致癌作用：2-芴基乙酰胺结合形式的持久性。

Chemical carcinogenesis: persistence of bound forms of 2-fluorenylacetamide.

作者信息

Epstein S M, McNary J, Bartus B, Farber E

出版信息

Science. 1968 Nov 22;162(3856):907-8. doi: 10.1126/science.162.3856.907.

DOI:10.1126/science.162.3856.907
PMID:5684496
Abstract

The persistent binding of metabolites of hepatic carcinogen, 2-fluorenylacetamide, to glycogen and to DNA in a new population of liver cells, hyperplastic nodules, and to glycogen in liver cancer cells weeks to months after the carcinogen was removed from the animals' diet is indicated by spectrophotometric, chromatographic, and mass spectrographic data. This persistence of binding does not appear to occur in the nonhyperplastic or nonneoplastic liver surrounding the nodules or the cancer.

摘要

分光光度法、色谱法和质谱法数据表明，在从动物饮食中去除致癌物数周乃至数月后，肝癌致癌物2-芴基乙酰胺的代谢产物持续与一群新的肝细胞、增生性结节中的糖原和DNA以及肝癌细胞中的糖原结合。在结节或癌症周围的非增生性或非肿瘤性肝脏中，似乎不会出现这种结合的持续性。

相似文献

1
Chemical carcinogenesis: persistence of bound forms of 2-fluorenylacetamide.化学致癌作用：2-芴基乙酰胺结合形式的持久性。
Science. 1968 Nov 22;162(3856):907-8. doi: 10.1126/science.162.3856.907.
2
Cellular analysis of liver carcinogenesis: the induction of large hyperplastic nodules in the liver with 2-fluorenylacetamide or ethionine and some aspects of their morphology and glycogen metabolism.肝癌发生的细胞分析：用2-芴基乙酰胺或乙硫氨酸诱导肝脏中的大的增生性结节及其形态学和糖原代谢的某些方面。
Cancer Res. 1967 Sep;27(9):1702-11.
3
Gangliosides of liver tumors induced by N-2-fluorenylacetamide. I. Ganglioside alterations in liver tumorigenesis and normal development.N-2-芴基乙酰胺诱导的肝肿瘤神经节苷脂。I. 肝肿瘤发生和正常发育过程中的神经节苷脂变化
J Natl Cancer Inst. 1978 Jun;60(6):1313-27. doi: 10.1093/jnci/60.6.1313.
4
The cellular analysis of liver carcinogenesis: ultrastructural alterations within hyperplastic liver nodules induced by 2-fluorenylacetamide.肝癌发生的细胞分析：2-芴基乙酰胺诱导的增生性肝结节内的超微结构改变。
Cancer Res. 1967 Sep;27(9):1712-21.
5
[Hyperplastic foci in chemical carcinogenesis].[化学致癌作用中的增生性病灶]
Tsitologiia. 1976 Sep;18(9):1104-10.
6
Histochemical correlation between glycogen, nucleic acids and nucleases in pre-neoplastic and neoplastic lesions of rat liver after short-term administration of N-nitrosomorpholine.短期给予N-亚硝基吗啉后大鼠肝脏癌前病变和肿瘤病变中糖原、核酸与核酸酶的组织化学相关性
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1976 Sep 24;87(1):53-65. doi: 10.1007/BF00285074.
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Quantitative kinetics of development of N-2-fluorenylacetamide-induced, altered (hyperplastic) hepatocellular foci resistant to iron accumulation and of their reversion or persistence following removal of carcinogen.N-2-芴基乙酰胺诱导的、对铁积累有抗性的改变（增生性）肝细胞灶发展的定量动力学，以及致癌物去除后它们的逆转或持续情况。
J Natl Cancer Inst. 1978 Jul;61(1):113-21. doi: 10.1093/jnci/61.1.113.
8
Cellular analysis of liver carcinogenesis. 3. Comparison of the ultrastructure of hyperplastic liver nodules and hepatocellular carcinomas induced in rat liver by 2-fluorenylacetamide.肝癌发生的细胞分析。3. 2-芴基乙酰胺诱导大鼠肝脏产生的增生性肝结节与肝细胞癌的超微结构比较。
J Natl Cancer Inst. 1969 Jul;43(1):33-63.
9
Unscheduled DNA synthesis in cells from N-2-fluorenylacetamide-induced hyperplastic nodules of rat liver maintained in a primary culture system.在原代培养系统中维持的、由N-2-芴基乙酰胺诱导的大鼠肝脏增生性结节细胞中的非程序性DNA合成。
Cancer Res. 1975 Dec;35(12):3682-92.
10
Growth in vitro of cells from hyperplastic nodules of liver induced by 2-fluorenylacetamide or aflatoxin B1.由2-芴基乙酰胺或黄曲霉毒素B1诱导的肝增生性结节细胞的体外生长
Science. 1970 Jan 16;167(3916):285-7. doi: 10.1126/science.167.3916.285.

引用本文的文献

1
Induction of cytokinin-independent tobacco tissues by substituted fluorenes.取代芴诱导不依赖细胞分裂素的烟草组织
Proc Natl Acad Sci U S A. 1971 Jun;68(6):1178-9. doi: 10.1073/pnas.68.6.1178.
2
Quantitative in situ image analysis of apoptosis in well and poorly differentiated tumors from rat liver.大鼠肝脏高分化和低分化肿瘤细胞凋亡的定量原位图像分析
Am J Pathol. 1995 Dec;147(6):1626-32.
3
Histofluorescence technique for the intracellular localization of chemical carcinogens.用于化学致癌物细胞内定位的组织荧光技术。
Histochem J. 1980 Nov;12(6):631-40. doi: 10.1007/BF01012018.
4
[The activation of carcinogenic aromatic amines in metabolism].[致癌性芳香胺在代谢中的活化作用]
Klin Wochenschr. 1970 Aug 15;48(16):959-66. doi: 10.1007/BF01484398.
5
Identification of epoxide hydrase as the preneoplastic antigen in rat liver hyperplastic nodules.鉴定环氧化物水解酶为大鼠肝脏增生性结节中的癌前抗原。
Proc Natl Acad Sci U S A. 1978 Jul;75(7):3240-3. doi: 10.1073/pnas.75.7.3240.