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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

McPherson T A, Koch M, Coates J E

Clin Biochem. 1978 Aug;11(4):169-71. doi: 10.1016/s0009-9120(78)90417-4.

A radioimmunoassay for CEA using commercially available reagents (CEA-Roche), which avoids the perchloric acid and dialysis steps used in the CEA-Roche assay, has been devised. 2. Comparison of results on 746 plasma samples using our assay with those obtained using the CEA-Roche assay revealed a highly significant correlation coefficient (0.72; p less than 0.00001). 3. A further comparison of results on 373 plasma samples using our assay, but including a preincubation step with goat serum, with those obtained using the CEA-Roche assay also revealed a highly significant correlation coefficient (0.89; 0.00001). The goat serum preincubation step eliminated most of the discordant results in which our assay value was higher than CEA-Roche assay, presumably because of anti-goat antibodies in the patient plasma sample.

已设计出一种使用市售试剂（癌胚抗原 - 罗氏检测法）检测癌胚抗原的放射免疫分析方法，该方法避免了罗氏癌胚抗原检测法中使用的高氯酸和透析步骤。2. 对746份血浆样本使用我们的检测方法与使用罗氏癌胚抗原检测法获得的结果进行比较，发现相关系数非常显著（0.72；p小于0.00001）。3. 对373份血浆样本使用我们的检测方法（包括与山羊血清进行预孵育步骤）与使用罗氏癌胚抗原检测法获得的结果进行进一步比较，也发现相关系数非常显著（0.89；p小于0.00001）。山羊血清预孵育步骤消除了大部分我们的检测值高于罗氏癌胚抗原检测法的不一致结果，这可能是由于患者血浆样本中存在抗山羊抗体。

McPherson T A, Koch M, Coates J E

Clin Biochem. 1978 Aug;11(4):169-71. doi: 10.1016/s0009-9120(78)90417-4.

A radioimmunoassay for CEA using commercially available reagents (CEA-Roche), which avoids the perchloric acid and dialysis steps used in the CEA-Roche assay, has been devised. 2. Comparison of results on 746 plasma samples using our assay with those obtained using the CEA-Roche assay revealed a highly significant correlation coefficient (0.72; p less than 0.00001). 3. A further comparison of results on 373 plasma samples using our assay, but including a preincubation step with goat serum, with those obtained using the CEA-Roche assay also revealed a highly significant correlation coefficient (0.89; 0.00001). The goat serum preincubation step eliminated most of the discordant results in which our assay value was higher than CEA-Roche assay, presumably because of anti-goat antibodies in the patient plasma sample.

已设计出一种使用市售试剂（癌胚抗原 - 罗氏检测法）检测癌胚抗原的放射免疫分析方法，该方法避免了罗氏癌胚抗原检测法中使用的高氯酸和透析步骤。2. 对746份血浆样本使用我们的检测方法与使用罗氏癌胚抗原检测法获得的结果进行比较，发现相关系数非常显著（0.72；p小于0.00001）。3. 对373份血浆样本使用我们的检测方法（包括与山羊血清进行预孵育步骤）与使用罗氏癌胚抗原检测法获得的结果进行进一步比较，也发现相关系数非常显著（0.89；p小于0.00001）。山羊血清预孵育步骤消除了大部分我们的检测值高于罗氏癌胚抗原检测法的不一致结果，这可能是由于患者血浆样本中存在抗山羊抗体。