胰多肽在人体中的药代动力学。
Pharmacokinetics of pancreatic polypeptide in man.
作者信息
Adrian T E, Greenberg G R, Besterman H S, Bloom S R
出版信息
Gut. 1978 Oct;19(10):907-9. doi: 10.1136/gut.19.10.907.
Abstract
Pure bovine pancreatic polypeptide (PP) was infused into 23 healthy subjects at doses of 1, 3, and 5 pmol/kg/min over 60 minutes and plasma PP was measured by radioimmunoassay. During the infusions mean plasma levels of 203 +/- 34, 575 +/- 73, and 930 +/- 48 pmol/l respectively were achieved. Mean disappearance half time on stopping the infusion was 6.9 +/- 0.3 min (mean +/- SEM). The metabolic clearance rate was 5.1 +/- 0.2 ml/kg/min (mean +/- SEM) and the apparent volume of distribution was calculated to be 51 +/- 3 ml/kg (mean +/- SEM). This study provides for the first time pharmacokinetic data for PP in man.
摘要
将纯牛胰多肽（PP）以1、3和5皮摩尔/千克/分钟的剂量在60分钟内输注给23名健康受试者，并通过放射免疫分析法测定血浆PP。在输注过程中，分别达到了平均血浆水平203±34、575±73和930±48皮摩尔/升。停止输注后的平均消失半衰期为6.9±0.3分钟（平均值±标准误）。代谢清除率为5.1±0.2毫升/千克/分钟（平均值±标准误），计算得出的表观分布容积为51±3毫升/千克（平均值±标准误）。本研究首次提供了PP在人体中的药代动力学数据。
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