The inhibition of chymotrypsin A4 and B with chloromethyl ketone reagents.
作者信息
Stevenson K J, Smillie L B
出版信息
Can J Biochem. 1968 Nov;46(11):1357-70. doi: 10.1139/o68-206.
DOI:10.1139/o68-206
PMID:5687069
Abstract
摘要
相似文献
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The inhibition of chymotrypsin A4 and B with chloromethyl ketone reagents.用氯甲基酮试剂对胰凝乳蛋白酶A4和B的抑制作用。
Can J Biochem. 1968 Nov;46(11):1357-70. doi: 10.1139/o68-206.
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The inhibition of chymotrypsin A4 with a homologous series of chloromethyl ketone reagents.用一系列同源氯甲基酮试剂对胰凝乳蛋白酶A4的抑制作用。
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Specific modification of methionine-192 of -chymotrypsin by an affinity label exploiting the orienting properties of the linear acetylenic group.利用线性炔基的定向特性，通过亲和标记对α-胰凝乳蛋白酶的甲硫氨酸-192进行特异性修饰。
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Structural and steric specificity of alpha-chloroketones as inhibitors of alpha-chymotrypsin.α-氯代酮作为α-胰凝乳蛋白酶抑制剂的结构和空间特异性
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Substrate binding site in bovine chymotrypsin A-gamma. A crystallographic study using peptide chloromethyl ketones as site-specific inhibitors.牛胰凝乳蛋白酶A-γ中的底物结合位点。使用肽氯甲基酮作为位点特异性抑制剂的晶体学研究。
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Subtilisin BPN': inactivation by chloromethyl ketone derivates of peptide substrates.枯草杆菌蛋白酶BPN'：肽底物的氯甲基酮衍生物使其失活
Arch Biochem Biophys. 1970 Jun;138(2):526-31. doi: 10.1016/0003-9861(70)90377-2.
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Kinetics of the reaction of chymotrypsin A with peptide chloromethyl ketones in relation to its subsite specificity.胰凝乳蛋白酶A与肽氯甲基酮反应的动力学及其亚位点特异性
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The reaction of phenoxymethyl chloromethyl ketone with nitrogen 3 of histidine-57 of chymotrypsin.苯氧甲基氯甲基酮与胰凝乳蛋白酶组氨酸-57的氮3的反应。
J Mol Biol. 1965 Jul;12(3):937-41. doi: 10.1016/s0022-2836(65)80342-4.
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Inactivation of alpha-chymotrypsin by a bifunctional reagent, 2-bromomethyl-3, I-benzoxazin-4-one.
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Evidence for an active-center cysteine in the SH-proteinase alpha-clostripain through use of N-tosyl-L-lysine chloromethyl ketone.通过使用N-对甲苯磺酰-L-赖氨酸氯甲基酮证明SH蛋白酶α-梭菌蛋白酶中存在活性中心半胱氨酸。
FEBS Lett. 1984 Jul 23;173(1):58-62. doi: 10.1016/0014-5793(84)81017-0.
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The selective isolation of an active-site histidine peptide from chymotrypsin-alpha by diagonal peptide 'mapping'. An N-tau-carboxymethylhistidine diagonal peptide "mapping.".通过对角线肽“图谱分析”从α-胰凝乳蛋白酶中选择性分离活性位点组氨酸肽。一种N-τ-羧甲基组氨酸对角线肽“图谱分析”。
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A 13C-n.m.r. investigation of the ionizations within an inhibitor--alpha-chymotrypsin complex. Evidence that both alpha-chymotrypsin and trypsin stabilize a hemiketal oxyanion by similar mechanisms.抑制剂-α-糜蛋白酶复合物内电离作用的13C核磁共振研究。α-糜蛋白酶和胰蛋白酶通过相似机制稳定半缩酮氧阴离子的证据。
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A study of the relaxation parameters of a 13C-enriched methylene carbon and a 13C-enriched perdeuteromethylene carbon attached to chymotrypsin.一项关于与胰凝乳蛋白酶相连的富含13C的亚甲基碳和富含13C的全氘代亚甲基碳的弛豫参数的研究。
Biochem J. 1991 Dec 15;280 ( Pt 3)(Pt 3):649-57. doi: 10.1042/bj2800649.
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Chymotrypsins from the deer (Cervidae) family. Isolation, partial characterization and primary-structure studies of chymotrypsins A and B from both moose (Alces alces) and elk (Cervus elaphus) pancreas.鹿科动物的胰凝乳蛋白酶。驼鹿（Alces alces）和马鹿（Cervus elaphus）胰腺中胰凝乳蛋白酶A和B的分离、部分特性鉴定及一级结构研究。
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