胍乙啶对大鼠内脏神经刺激所致血压反应的影响：肾上腺髓质的作用。
Effects of guanethidine on the blood pressure response to splanchnic nerve stimulation in the rat: role of the adrenal medulla.
作者信息
Carpi A, Cartoni C
出版信息
Br J Pharmacol. 1968 Oct;34(2):259-66. doi: 10.1111/j.1476-5381.1968.tb07049.x.
Abstract
- Splanchnic nerve stimulation provokes a larger increase in blood pressure in intact rats than in rats previously demedullated by means of expression of the adrenals in situ and adrenalectomy followed by adrenocortical grafting.2. Rats pretreated with guanethidine showed an attenuated albeit prolonged hypertensive response to splanchnic stimulation. Similar effects were exerted by guanethidine in rats demedullated by expression. In rats demedullated by grafting, smaller doses of guanethidine induced a more substantial depression of the blood pressure response without increasing its duration.3. It is concluded that inhibition of the peripheral sympathetic endings induced by guanethidine was partially compensated by the enhancement of the cardiovascular effects of the mediators released by the adrenal medulla and that demedullation by expression did not completely eliminate chromaffin tissue.
摘要
与通过原位肾上腺表达及肾上腺切除后进行肾上腺皮质移植而预先去髓质的大鼠相比，内脏神经刺激在完整大鼠中引起的血压升高幅度更大。
用胍乙啶预处理的大鼠对内脏刺激的高血压反应虽有所减弱但持续时间延长。胍乙啶对通过表达去髓质的大鼠也有类似作用。在通过移植去髓质的大鼠中，较小剂量的胍乙啶即可引起血压反应更显著的降低，且不会延长其持续时间。
得出的结论是，胍乙啶诱导的外周交感神经末梢抑制被肾上腺髓质释放的介质的心血管效应增强所部分补偿，并且通过表达去髓质并未完全消除嗜铬组织。
相似文献
1
Effects of guanethidine on the blood pressure response to splanchnic nerve stimulation in the rat: role of the adrenal medulla.胍乙啶对大鼠内脏神经刺激所致血压反应的影响：肾上腺髓质的作用。
Br J Pharmacol. 1968 Oct;34(2):259-66. doi: 10.1111/j.1476-5381.1968.tb07049.x.
2
Mechanism of the antagonism of the hypotensive action of guanethidine by propranolol.普萘洛尔对抗胍乙啶降压作用的机制。
Br J Pharmacol. 1970 Apr;38(4):771-5. doi: 10.1111/j.1476-5381.1970.tb09886.x.
3
Adrenocortical and adrenomedullary factors influencing the blood pressure response to splanchnic stimulation in the rat.影响大鼠对内脏刺激血压反应的肾上腺皮质和肾上腺髓质因素。
Ann Ist Super Sanita. 1968;4(3):338-40.
4
Sympathetic control of lower esophageal sphincter function in the cat. Action of direct cervical and splanchnic nerve stimulation.猫下食管括约肌功能的交感神经控制。颈神经和内脏神经直接刺激的作用。
J Clin Invest. 1979 Apr;63(4):562-70. doi: 10.1172/JCI109337.
5
Comparison of the hyperglycaemic and glycogenolytic responses to catecholamines with those to stimulation of the hepatic sympathetic innervation in the dog.犬体内儿茶酚胺引起的高血糖和糖原分解反应与刺激肝交感神经支配所引起的反应的比较。
J Physiol. 1972 Jun;223(2):571-93. doi: 10.1113/jphysiol.1972.sp009863.
6
7
The action of guanethidine with particular reference to the sympathetic nervous system.胍乙啶的作用，特别涉及交感神经系统。
Br J Pharmacol Chemother. 1963 Feb;20(1):171-7. doi: 10.1111/j.1476-5381.1963.tb01307.x.
8
Evidence for an adrenergic innervation of the adrenal cortical blood vessels in rats.大鼠肾上腺皮质血管肾上腺素能神经支配的证据。
Acta Physiol Scand. 1993 Sep;149(1):23-30. doi: 10.1111/j.1748-1716.1993.tb09588.x.
9
The role of the adrenal medulla in the blood pressure response to carbon dioxide following hexamethonium.六甲铵作用后肾上腺髓质在对二氧化碳的血压反应中的作用。
Arch Int Pharmacodyn Ther. 1966 Mar;160(1):29-43.
10
Chronic guanethidine and adrenal medullary function in the rat.大鼠慢性胍乙啶与肾上腺髓质功能
J Pharm Pharmacol. 1976 Oct;28(10):785-6. doi: 10.1111/j.2042-7158.1976.tb04052.x.
引用本文的文献
1
Unilateral lesions of the auditory cortex and the 'precedence effect'.听觉皮层的单侧损伤与“优先效应”
J Physiol. 1971 Mar;213(2):24P-25P.
2
Blood pressure responses to adrenal field stimulation as a measure of adrenal catecholamine release.作为肾上腺儿茶酚胺释放量指标的血压对肾上腺区域刺激的反应。
Br J Pharmacol. 1976 Mar;56(3):271-7. doi: 10.1111/j.1476-5381.1976.tb07638.x.
本文引用的文献
1
INTERACTION OF GUANETHIDINE WITH ADRENERGIC NEURONS.胍乙啶与肾上腺素能神经元的相互作用。
J Pharmacol Exp Ther. 1965 Mar;147:303-12.
2
URINARY EXCRETION OF CATECHOL AMINES IN THE RAT AFTER THEIR LIBERATION BY RESERPINE OR DEXAMPHETAMINE.利血平或右旋苯丙胺释放后大鼠尿中儿茶酚胺的排泄情况
Br J Pharmacol Chemother. 1964 Dec;23(3):529-39. doi: 10.1111/j.1476-5381.1964.tb01608.x.
3
The action of guanethidine with particular reference to the sympathetic nervous system.胍乙啶的作用，特别涉及交感神经系统。
Br J Pharmacol Chemother. 1963 Feb;20(1):171-7. doi: 10.1111/j.1476-5381.1963.tb01307.x.
4
Tissue amine levels and sympathetic blockade after guanethidine and bretylium.胍乙啶和溴苄铵后的组织胺水平及交感神经阻滞
Br J Pharmacol Chemother. 1961 Dec;17(3):442-50. doi: 10.1111/j.1476-5381.1961.tb01131.x.
5
The effects of guanethidine on the adrenal medulla.胍乙啶对肾上腺髓质的作用。
J Pharmacol Exp Ther. 1962 Aug;137:229-34.
6
Pharmacology of [2-(octahydro-1-azocinyl)-ethyl]-guanidine sulfate (Su-5864).[2-(八氢-1-氮杂环辛烷基)-乙基]-胍硫酸盐（Su-5864）的药理学
J Pharmacol Exp Ther. 1960 Jan;128:22-9.
7
Adrenal regeneration and adrenal-regeneration hypertension.肾上腺再生与肾上腺再生性高血压。
Physiol Rev. 1959 Jan;39(1):162-82. doi: 10.1152/physrev.1959.39.1.162.
8
The adrenal cortex and the sympathetic nervous system.肾上腺皮质与交感神经系统。
Physiol Rev. 1957 Apr;37(2):155-95. doi: 10.1152/physrev.1957.37.2.155.
9
Histochemical demonstration of noradrenaline and adrenaline in the adrenal medulla.肾上腺髓质中去甲肾上腺素和肾上腺素的组织化学显示。
J Histochem Cytochem. 1955 Jan;3(1):1-5. doi: 10.1177/3.1.1.
10
Zotero 插件