ABERCROMBIE G F, DAVIES B N
Br J Pharmacol Chemother. 1963 Feb;20(1):171-7. doi: 10.1111/j.1476-5381.1963.tb01307.x.
It has been suggested that guanethidine can release and then deplete postganglionic sympathetic nerve endings of noradrenaline. However, no release of noradrenaline from postganglionic nerve endings or from the adrenal medulla by guanethidine was found by direct experiment. Although release of noradrenaline from postganglionic sympathetic nerve endings in response to nerve stimulation was rapidly reduced and finally abolished by guanethidine, the drug did not appear to affect the release of catechol amines from the adrenal medulla in response to splanchnic nerve stimulation. The nature of the action of guanethidine is discussed, and it is concluded that it blocks the effect of postganglionic sympathetic nerve stimulation by interfering with the synthesis of transmitter and that it also has a direct sympathomimetic effect.
有人提出，胍乙啶能释放节后交感神经末梢的去甲肾上腺素，然后使其耗竭。然而，通过直接实验未发现胍乙啶能使节后神经末梢或肾上腺髓质释放去甲肾上腺素。尽管胍乙啶能迅速降低并最终消除节后交感神经末梢因神经刺激而引起的去甲肾上腺素释放，但该药物似乎并不影响肾上腺髓质因内脏神经刺激而引起的儿茶酚胺释放。文中讨论了胍乙啶作用的性质，并得出结论：它通过干扰递质的合成来阻断节后交感神经刺激的效应，并且它还具有直接的拟交感神经效应。
