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本文引用的文献

1
Treatment of Intractable Pain with Morphine and Tetrahydroaminacrine.吗啡与四氢氨基吖啶治疗顽固性疼痛
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2
Effect of hepatectomy upon the analgetic action of 1 methadone.肝切除术对1-美沙酮镇痛作用的影响。
Proc Soc Exp Biol Med. 1950 Jul;74(3):589-91. doi: 10.3181/00379727-74-17983.
3
The effect of the liver on the metabolism of d,1-methadone in vitro and in vivo.肝脏在体外和体内对消旋美沙酮代谢的影响。
J Pharmacol Exp Ther. 1950 Jan;98(1):72-6.
4
Morphine antagonism.吗啡拮抗作用。
Nature. 1952 Apr 26;169(4304):712-3. doi: 10.1038/169712a0.
5
The treatment of severe pain.重度疼痛的治疗。
Br J Clin Pract. 1960 Jan;14:23-8.
6
Treatment of intractable pain with large doses of morphine and diamino-phenylthiazole.大剂量吗啡和二氨基苯基噻唑治疗顽固性疼痛。
Br Med J. 1955 Jun 4;1(4926):1367-9. doi: 10.1136/bmj.1.4926.1367.
7
AMIPHENAZOLE IN THE TREATMENT OF MORPHINE AND OPIUM ADDICTION.安米芬唑治疗吗啡和鸦片成瘾
Lancet. 1964 May 9;1(7341):1010-2. doi: 10.1016/s0140-6736(64)91922-1.
8
The biological disposition of morphine and its surrogates. I.吗啡及其替代物的生物处置。I.
Bull World Health Organ. 1961;25(2):227-62.
9
The preparation of tritium nuclear-labeled morphine and evidence for its in vivo biotransformation to normorphine in the rat.氚核标记吗啡的制备及其在大鼠体内生物转化为去甲吗啡的证据。
J Pharmacol Exp Ther. 1961 Jun;132:317-22.
10
Excretion of urinary N-C14-methyl morphine and pulmonary C14O2 in the monkey and dog after subcutaneous injection of the labelled drug.
Proc Soc Exp Biol Med. 1961 Jan;106:221-3. doi: 10.3181/00379727-106-26293.

吗啡 - N - 氧化物的镇痛作用。

The analgesic action of morphine-n-oxide.

作者信息

Fennessy M R

出版信息

Br J Pharmacol. 1968 Oct;34(2):337-44. doi: 10.1111/j.1476-5381.1968.tb07055.x.

DOI:10.1111/j.1476-5381.1968.tb07055.x
PMID:5687589
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1703337/
Abstract
  1. The analgesic activity of morphine-N-oxide in mice and rats has been investigated and compared with that of morphine.2. Both morphine and morphine-N-oxide were more active when given subcutaneously than when given intraperitoneally.3. Given subcutaneously, morphine was 11-22 times more potent than morphine-N-oxide and when given intraperitoneally it was 39-89 times more potent. The potencies depended on the test situation and the species of animal used.4. In animals pretreated with amiphenazole or tacrine, the analgesic activities of morphine and morphine-N-oxide were increased. The potencies of these analgesic drugs given intraperitoneally were increased to a greater extent than were the potencies obtained by subcutaneous administration.5. A possible explanation for the increase in analgesic potency of morphine-N-oxide produced by pretreatment with amiphenazole or tacrine may be that morphine-N-oxide is rapidly inactivated in the liver and this inactivation is impaired by amiphenazole and tacrine.
摘要

  1. 已对氧化吗啡在小鼠和大鼠中的镇痛活性进行了研究，并与吗啡的镇痛活性作了比较。

  2. 吗啡和氧化吗啡皮下给药时均比腹腔给药时活性更强。

  3. 皮下给药时，吗啡的效力比氧化吗啡强11至22倍，腹腔给药时则强39至89倍。效力取决于试验情况及所用动物的种类。

  4. 在预先用安米苯唑或他克林处理过的动物中，吗啡和氧化吗啡的镇痛活性增强。这些镇痛药腹腔给药时效力的增强程度比皮下给药时更大。

  5. 用安米苯唑或他克林预处理使氧化吗啡镇痛效力增强的一个可能解释是，氧化吗啡在肝脏中迅速失活，而安米苯唑和他克林会损害这种失活过程。