Branda L A, Ferrier B M, Archimaut G, Marchelli E A, Rucanski B
Science. 1968 Apr 5;160(3823):81-2. doi: 10.1126/science.160.3823.81.
Incubation of deamino-oxytocin with plasma obtained from women in labor reduced the potency of this analog of oxytocin when assayed on an isolated strip of mammary gland taken from a lactating rat. Plasmas of nonpregnant women had no detectable effect on this activity of deamino-oxytocin, and the effect of plasmas from women just previous to the beginning of labor was not significant. The original. activities of the incubated deamino-oxytocin solutions could be restored by treatment with hydrogen peroxide. The inactivation may be caused by reductive cleavage of the disulfide bridge of deamino-oxytocin, this bridge being reformed by oxidation.
将脱氨基催产素与分娩期妇女的血浆一起温育后，在取自泌乳大鼠的乳腺离体条带上进行测定时，该催产素类似物的效力降低。未怀孕妇女的血浆对脱氨基催产素的这种活性没有可检测到的影响，临产前妇女的血浆的影响也不显著。经过氧化氢处理后，温育的脱氨基催产素溶液的原始活性可以恢复。这种失活可能是由于脱氨基催产素二硫键的还原断裂所致，该二硫键可通过氧化重新形成。
