Evers K G, Thouet R, Haase W, Krüger J
Eur J Pediatr. 1978 Dec 1;129(4):267-72. doi: 10.1007/BF00441357.
26 patients with an acute reversible ITP and 6 with chronic ITP were tissue typed, together with their healthy first-degree relatives. The HLA frequencies of the different groups were compared with those of a normal control population. The only significant difference between the groups was an increase in the frequency of Aw32 in acute ITP patients. HLA-Aw32 was present in 26.9% of patients, but in only 0.8% of the controls (corrected P = 0.000027). The possible importance of associations between antigens of the HLA-A locus with certain diseases are discussed. Family analyses and haplotype determinations proved to be unproductive because no familial clustering of ITP was found.
对26例急性可逆性免疫性血小板减少性紫癜（ITP）患者和6例慢性ITP患者及其健康的一级亲属进行了组织分型。将不同组的人类白细胞抗原（HLA）频率与正常对照人群的频率进行了比较。各组之间唯一显著的差异是急性ITP患者中Aw32频率增加。HLA - Aw32在26.9%的患者中存在，但在仅0.8%的对照中存在（校正P = 0.000027）。讨论了HLA - A位点抗原与某些疾病之间关联的可能重要性。由于未发现ITP的家族聚集现象，家族分析和单倍型测定结果未产生有效信息。
