Meyer-Burgdorff C, Seidel G, Wolf I
Anaesthesist. 1976 Jan;25(1):1-5.
Injection of Epontol (7 mg/kg i.v.) to male healthy students caused a brief increase in plasma histamine concentration from 0.7 ng/ml to 3.0 ng/ml. Combined injection (7 mg/kg) and infusion of Epontol (21 mg/kg during 15 min) or combined injection of Epontol (7 mg/kg) and suxamethonium (0.5 mg/kg) caused a more prolonged appearance of histamine in plasma without higher maximum concentrations. During anaesthesia with ketamine (Ketanest), halothane or nitrous oxide the histamine concentrations in plasma remained unaltered.
给健康男性学生静脉注射埃蓬托尔（7毫克/千克），导致血浆组胺浓度从0.7纳克/毫升短暂升高至3.0纳克/毫升。联合注射（7毫克/千克）并输注埃蓬托尔（15分钟内21毫克/千克）或联合注射埃蓬托尔（7毫克/千克）和琥珀酰胆碱（0.5毫克/千克），可使血浆中组胺出现时间延长，但最高浓度未升高。在使用氯胺酮（凯他敏）、氟烷或氧化亚氮麻醉期间，血浆中的组胺浓度保持不变。
