Beggs W H, Andrews F A
Antimicrob Agents Chemother. 1976 Mar;9(3):393-6. doi: 10.1128/AAC.9.3.393.
To better understand salt antagonism of dihydrostreptomycin (DSM) action on Mycobacterium smegmatis, the effects of monovalent and divalent cation salts on drug uptake were studied in relation to the lethal activity of DSM. In Sauton liquid medium NaCl, MgCl(2), and SrCl(2) inhibited the initial instantaneous binding of [(3)H]DSM to the organism and suppressed secondary uptake. These data correlated well with the capacity of each salt to prevent the lethal activity of DSM. It was concluded that monovalent and divalent cation salt antagonism of DSM action on M. smegmatis involves nonspecific interference with drug uptake.
为了更好地理解二氢链霉素（DSM）对耻垢分枝杆菌作用的盐拮抗作用，研究了单价和二价阳离子盐对药物摄取的影响及其与DSM致死活性的关系。在索顿液体培养基中，NaCl、MgCl₂和SrCl₂抑制了[³H]DSM与该菌的初始瞬时结合，并抑制了二次摄取。这些数据与每种盐阻止DSM致死活性的能力密切相关。得出的结论是，单价和二价阳离子盐对DSM作用于耻垢分枝杆菌的拮抗作用涉及对药物摄取的非特异性干扰。
