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1
Gentamicin does not chelate calcium.庆大霉素不螯合钙。
Antimicrob Agents Chemother. 1982 Apr;21(4):668-9. doi: 10.1128/AAC.21.4.668.
2
[Alkaline earth chelates from hydrolytically cleavable chelate constituents, I. On the calcium chelate of the N-glucoside of dimethylamino-alpha, alpha'-dicarboxylic acid (iminodiacetic acid)].[来自可水解裂解螯合成分的碱土金属螯合物，I. 关于二甲基氨基-α,α'-二羧酸（亚氨基二乙酸）N-葡萄糖苷的钙螯合物]
Hoppe Seylers Z Physiol Chem. 1967 Nov;348(11):1505-8.
3
An explantation for the apparent chelation of calcium by tetrodotoxin.
Biochem Biophys Res Commun. 1968 Mar 12;30(5):528-33. doi: 10.1016/0006-291x(68)90084-3.
4
Proposed mechanism for gentamicin transport.
J Pharm Sci. 1973 Jan;62(1):167-8. doi: 10.1002/jps.2600620141.
5
The apparent binding constant of glycoletherdiaminetetraacetic acid for calcium at neutral pH.乙二醇醚二胺四乙酸在中性pH条件下对钙的表观结合常数。
J Biochem. 1968 Aug;64(2):255-7. doi: 10.1093/oxfordjournals.jbchem.a128887.
6
Selective N-actylation of gentamicin antibiotics-synthesis of 1-N-acyl derivatives.庆大霉素抗生素的选择性N-酰化反应——1-N-酰基衍生物的合成
J Antibiot (Tokyo). 1976 Jul;29(7):714-9. doi: 10.7164/antibiotics.29.714.
7
Antibacterial activity of gentamicin in urine and tryptose phosphate broth.庆大霉素在尿液和胰蛋白胨磷酸盐肉汤中的抗菌活性。
Chemioterapia. 1984 Apr;3(2):97-101.
8
Drug-biomolecule interactions: interaction of gentamicin with lipid monomolecular films.药物-生物分子相互作用：庆大霉素与脂质单分子膜的相互作用
J Pharm Sci. 1975 Mar;64(3):516-9. doi: 10.1002/jps.2600640343.
9
Studies on the metal chelation of chlorpromazine and its hydroxylated metabolites.
Adv Biochem Psychopharmacol. 1974;9(0):571-91.
10
A sensitive spectrophotometric method for the determination of human serum albumin with chrome-azurol S aluminium chelate.一种用铬天青S铝螯合物测定人血清白蛋白的灵敏分光光度法。
Chem Pharm Bull (Tokyo). 1986 Feb;34(2):746-50. doi: 10.1248/cpb.34.746.

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1
Characterization of biofilm formed by human-derived nanoparticles.人源纳米颗粒形成的生物膜的特性。
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2
Localization of the nephron site of gentamicin-induced hypercalciuria in the rat: a micropuncture study.庆大霉素诱导的大鼠高钙尿症肾单位部位的定位：一项微穿刺研究。
Br J Pharmacol. 2000 May;130(2):441-9. doi: 10.1038/sj.bjp.0703329.

本文引用的文献

1
Metal chelates of streptomycin.链霉素的金属螯合物
J Am Pharm Assoc Am Pharm Assoc. 1955 May;44(5):261-3. doi: 10.1002/jps.3030440503.
2
Binding of aminocyclitol antibiotics to kidney and intestinal brush border membranes.氨基环醇类抗生素与肾脏及肠道刷状缘膜的结合。
J Antibiot (Tokyo). 1981 Jan;34(1):103-13. doi: 10.7164/antibiotics.34.103.
3
Involvement of the outer membrane in gentamicin and streptomycin uptake and killing in Pseudomonas aeruginosa.铜绿假单胞菌外膜在庆大霉素和链霉素摄取及杀菌过程中的作用
Antimicrob Agents Chemother. 1981 May;19(5):777-85. doi: 10.1128/AAC.19.5.777.
4
Relation of aerobiosis and ionic strength to the uptake of dihydrostreptomycin in Escherichia coli.
Biochim Biophys Acta. 1980 Nov 5;593(1):1-10. doi: 10.1016/0005-2728(80)90002-x.
5
A new method for determining micro quantities of calcium in biological materials.
Anal Biochem. 1967 Jul;20(1):155-66. doi: 10.1016/0003-2697(67)90273-4.
6
Effect of medium composition on the apparent sensitivity of Pseudomonas aeruginosa to gentamicin.培养基成分对铜绿假单胞菌对庆大霉素表观敏感性的影响。
J Clin Pathol. 1969 Sep;22(5):534-8. doi: 10.1136/jcp.22.5.534.
7
Activity of aminoglycoside antibiotics aganst Pseudomonas aeruginosa: specificity and site of calcium and magnesium antagonism.氨基糖苷类抗生素对铜绿假单胞菌的活性：钙和镁拮抗作用的特异性及位点
J Infect Dis. 1973 Jun;127(6):663-9. doi: 10.1093/infdis/127.6.663.
8
Accelerating effect of Cu++ chelate of kanamycin on oxidation of L-ascorbic acid.卡那霉素铜螯合物对L-抗坏血酸氧化的加速作用。
Jpn J Pharmacol. 1967 Mar;17(1):138. doi: 10.1254/jjp.17.138.
9
Effect of cation content of agar on the activity of gentamicin, tobramycin, and amikacin against Pseudomonas aeruginosa.琼脂阳离子含量对庆大霉素、妥布霉素和阿米卡星抗铜绿假单胞菌活性的影响。
J Infect Dis. 1978 Feb;137(2):103-11. doi: 10.1093/infdis/137.2.103.
10
Effects of membrane-energy mutations and cations on streptomycin and gentamicin accumulation by bacteria: a model for entry of streptomycin and gentamicin in susceptible and resistant bacteria.膜能量突变和阳离子对细菌积累链霉素和庆大霉素的影响：链霉素和庆大霉素进入敏感菌和耐药菌的模型
Antimicrob Agents Chemother. 1977 Aug;12(2):163-77. doi: 10.1128/AAC.12.2.163.

庆大霉素不螯合钙。

Gentamicin does not chelate calcium.

作者信息

Kohlhepp S J, Plant S B, McCarron D A, Gilbert D N

出版信息

Antimicrob Agents Chemother. 1982 Apr;21(4):668-9. doi: 10.1128/AAC.21.4.668.

DOI:10.1128/AAC.21.4.668
PMID:7081982
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC181964/
Abstract

The influence of increasing gentamicin concentrations on ionized calcium concentration was determined in pH-controlled, phosphate-buffered saline and normal human serum with an ion-specific calcium electrode. No evidence of calcium chelation was found.

摘要

使用离子特异性钙电极，在pH值受控的磷酸盐缓冲盐水和正常人血清中，测定了庆大霉素浓度增加对离子钙浓度的影响。未发现钙螯合的证据。