一些与某些化疗药物结构相关的2-苯乙烯基喹唑啉衍生物的合成。
Synthesis of some 2-styrylquinazoline derivatives structurally related to certain chemotherapeutic agents.
作者信息
Botros S, Shaban M
出版信息
Pharmazie. 1978 Oct;33(10):646-7.
PMID:569334
Abstract
The synthesis of certain 2-styryl-4-arylaminoquinazolines having the general formula 1 is described. 4-Chloro-2-styrylquinazolines were prepared by chlorination of 2-styryl-4-quinazolones in benzene solution using phosphorus oxychloride and an excess of dimethylaniline. Reacting the chlorostyrylquinazolines with certain arylamines afforded 1.
摘要
描述了通式为1的某些2-苯乙烯基-4-芳基氨基喹唑啉的合成。4-氯-2-苯乙烯基喹唑啉是通过在苯溶液中用三氯氧磷和过量的二甲基苯胺对2-苯乙烯基-4-喹唑酮进行氯化制备的。使氯苯乙烯基喹唑啉与某些芳胺反应得到1。
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