[Changes in the endomembrane system and mitochondria of cultured chick fibroblasts upon application of colchicine and following its withdrawal].

After the administration of colchicine (5 mcg/ml) into nutritive medium of primary tissue culture there is a remarkable decrease in the volume and number of fibroblast-membrane organoids during the first 3 hours. The removing of colchicine-damaged fibroblasts into the medium without colchicine leads to the renewal of the most of intracellular membranes during the following 24 hours. Probable reasons and mechanisms of colchicine-induced alterations are discussed.