Schleissner L A, Sheehan W W, Orselli R C
Arthritis Rheum. 1976 Mar-Apr;19(2):249-55. doi: 10.1002/art.1780190220.
A patient with systemic lupus erythematosus of long duration developed secondary amyloidosis and finally died after the additional complication of malignant lymphoproliferative disease. Multiple system involvement, typical serologic findings, and postmortem evidence substantiated the diagnosis of lupus erythematosus. Amyloid deposition was found in several organs, but was notably extensive in the adrenal cortex. This extensive deposition resulted in adrenal insufficiency, which was diagnosed clinically and treated until the patient's death from lymphoma. The particular nature of the malignant lymphoma is emphasized; a distinctive feature was the disappearance of positive lupus erythematosus cells from the buffy coat and the reduction in titers of relevant serologic tests toward the end of the illness. In spite of this reduction, many hematoxylin bodies and abundant complete lupus erythematosus cells were found in the lungs on postmortem examination.
一名长期患有系统性红斑狼疮的患者发生了继发性淀粉样变性，最终在出现恶性淋巴增殖性疾病这一额外并发症后死亡。多系统受累、典型的血清学检查结果以及尸检证据证实了红斑狼疮的诊断。在多个器官中发现了淀粉样沉积，但在肾上腺皮质中尤为广泛。这种广泛的沉积导致了肾上腺功能不全，临床上已作出诊断并进行了治疗，直至患者死于淋巴瘤。文中强调了恶性淋巴瘤的特殊性质；一个显著特征是在病程末期，血沉棕黄层中阳性红斑狼疮细胞消失，相关血清学检查的滴度降低。尽管滴度降低，但尸检时在肺部发现了许多苏木精小体和大量完整的红斑狼疮细胞。
