醋酸可的松对19S和7S溶血素抗体的影响。一项时间进程研究。
Effect of cortisone acetate on 19S and 7S haemolysin antibody. A time course study.
作者信息
Elliott E V, Sinclair N R
出版信息
Immunology. 1968 Nov;15(5):643-52.
A single subcutaneous injectio of cortisone acetate (400–500 mg/kg body weight) depressed the serum haemolysin response of adult Swiss mice to sheep erythrocytes when administered near the time of antigen injection. The greatest suppression of the early haemolysin response occurred when cortisone was injected 3–4 days prior to antigen, while the late antibody response (20–30 days after antigen injection) was markedly decreased when cortisone was given up to 4 days after antigen. Cortisone depressed both 19S and 7S haemolysin when given prior to antigen, but depressed only the 7S antibody when administered after antigen. An attempt was made to correlate the depression of the immune response with the decrease in lymphoid tissue following cortisone treatment and a striking correlation was observed between the number of circulating lymphocytes at the time of antigen injection and the 7 day titres of total and 19S antibody.
当在抗原注射时间附近给予成年瑞士小鼠单次皮下注射醋酸可的松（400 - 500毫克/千克体重）时，会抑制其对绵羊红细胞的血清溶血素反应。当在抗原注射前3 - 4天注射可的松时，早期溶血素反应受到的抑制最大，而当在抗原注射后长达4天给予可的松时，晚期抗体反应（抗原注射后20 - 30天）则明显降低。在抗原注射前给予可的松会同时抑制19S和7S溶血素，但在抗原注射后给予则仅抑制7S抗体。尝试将免疫反应的抑制与可的松治疗后淋巴组织的减少相关联，并且在抗原注射时循环淋巴细胞的数量与7天总抗体和19S抗体滴度之间观察到了显著的相关性。
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