Foss G L, Svendsen E K, Fotherby K, Richards D J
Br Med J. 1968 Nov 23;4(5629):489-91. doi: 10.1136/bmj.4.5629.489.
Norgestrel in a dose of 50 mug. was administered daily to 188 women during 2,250 menstrual cycles. Only two pregnancies occurred because of failure of the method, giving a failure rate of 1.1 pregnancies per 100 woman-years. The method was acceptable to most of the subjects, and side-effects, other than menstrual irregularity, were minimal; 68% of the cycles were 28 +/-5 days in length and 21% were less than 23 days. There did not appear to be any increased incidence of amenorrhoea. The antifertility action of continuous administration of low doses of progestogen may be due to an effect on corpus luteum function, in addition to the effects on cervical mucus, endometrium, and tubal transport of ova. The optimum dose of norgestrel appears to be in the range of 50-75 mug./day.
在2250个月经周期中，对188名妇女每日给予50微克炔诺孕酮。因该方法失败仅发生了2次妊娠，失败率为每100妇女年1.1次妊娠。该方法为大多数受试者所接受，除月经不规律外，副作用极小；68%的周期长度为28±5天，21%的周期少于23天。闭经的发生率似乎没有增加。持续给予低剂量孕激素的抗生育作用，除了对宫颈黏液、子宫内膜和输卵管卵子运输的影响外，可能还归因于对黄体功能的影响。炔诺孕酮的最佳剂量似乎在每日50 - 75微克的范围内。
