Irey N S, McAllister H A, Henry J M
Neurology. 1978 Dec;28(12):1216-9. doi: 10.1212/wnl.28.12.1216.
Pathologic studies of women with fatal cerebrovascular disease who have received oral contraceptives are infrequently found in the literature. Three cases of this type are reported here. The pathologic findings included an intrinsic vascular lesion in the form of intimal hyperplasia with and without associated thrombosis, found in arteries supplying the brain. Similar vascular lesions have been reported previously in other sites of the vascular system in association with exogenous or endogenous steroids. They have also been found in other species under the influence of steroids. This hyperplasia of vessel intima may be found in association with other clinicopathologic entities, but stigmata of other diseases were not found in these three patients.
文献中很少能找到接受口服避孕药的致命性脑血管疾病女性的病理研究。本文报告了3例此类病例。病理结果包括在供应脑部的动脉中发现内膜增生形式的内在血管病变，伴有或不伴有相关血栓形成。先前在血管系统的其他部位也曾报道过与外源性或内源性类固醇相关的类似血管病变。在类固醇影响下的其他物种中也发现过此类病变。这种血管内膜增生可能与其他临床病理实体相关，但这3例患者未发现其他疾病的特征。
