Pomerance A
J Clin Pathol. 1968 May;21(3):317-21. doi: 10.1136/jcp.21.3.317.
The pathology of the heart was studied in 60 patients dying in their tenth decade in a general hospital. The severity of coronary atherosclerosis and the incidence of ischaemic heart disease was lower than in younger geriatric patients. The incidence of minor ;aging' changes was similar to that in younger patients with the exception of mitral valve atheroma where the increase with aging continued into the tenth decade. Marked nodular thickening of the tricuspid valve was seen only in males. Over half the systolic murmurs heard were associated with mitral valve abnormalities and not with aortic valve changes. Multiple cardiac pathology was more frequent than in younger patients but its association with failure was much less striking. It is concluded that resistance to the development of coronary atherosclerosis and to failure being precipitated by the multiple minor cardiac abnormalities associated with aging are important factors in attaining extreme longevity.
在一家综合医院对60例九十多岁死亡患者的心脏病理进行了研究。冠状动脉粥样硬化的严重程度和缺血性心脏病的发病率低于年轻老年患者。除二尖瓣粥样瘤外，轻度“衰老”变化的发生率与年轻患者相似，二尖瓣粥样瘤随年龄增长的情况在九十多岁时仍持续增加。仅在男性中发现三尖瓣明显的结节状增厚。所闻及的收缩期杂音半数以上与二尖瓣异常有关，而非主动脉瓣改变。多种心脏病理情况比年轻患者更常见，但与心力衰竭的关联远不如年轻患者明显。结论是，抵抗冠状动脉粥样硬化的发展以及抵抗与衰老相关的多种轻微心脏异常引发的心力衰竭，是实现极高寿的重要因素。
