[Proliferative kinetics of antibody-forming cells normally and exposed to vinblastine].

The proliferative kinetics of IgM antibody-producing cells (APC) of mice immunized by sheep red blood cells was studied using autoradiography and vinblastine. The incorporation index for APC was determined every 4 hours from 72 to 112 hours of the immune response. The significance of recruitment in APC exponential growth was proven by means of 3 different regimes of 3H-thymidine introduction to immunized mice. The discontinuous character of recruitment and its resistance to vinblastine were shown. It is suggested that vinblastine impared both APC and their precursors.