Palva M, Palkama A
Acta Ophthalmol (Copenh). 1978;56(4):587-98. doi: 10.1111/j.1755-3768.1978.tb01371.x.
The effect of in vivo X-irradiation on the ultrastructure of the rat lens was investigated by electron microscopy. The left eye of each animal was exposed to a single dose of 1500 r of X-rays, while the other parts of the body were protected by a lead shield. The protected eye served as a control. Samples of the lenses were taken for electron microscopical examination at intervals of 3, 7, 30, 60, 90 and 180 days after the irradiation. The first ultrastructural changes induced by X-rays were found after three days in the epithelial cells which became vacuolated. After seven days these cells showed marked oedema and after six months the whole epithelium was shrunken. The most prominent changes in the lens fibres were swelling and vacuolization. No alterations were noted in the lens capsule. The first visible opacities of the lens were found ninety days after irradiation under the posterior capsule and three months later the entire lens was totally opaque.
通过电子显微镜研究了体内X射线照射对大鼠晶状体超微结构的影响。每只动物的左眼接受单次1500伦琴的X射线照射，而身体的其他部位用铅屏蔽保护。受保护的眼睛作为对照。在照射后3、7、30、60、90和180天的间隔时间采集晶状体样本进行电子显微镜检查。X射线诱导的最初超微结构变化在三天后在上皮细胞中发现，这些细胞出现空泡化。七天后这些细胞显示出明显的水肿，六个月后整个上皮细胞萎缩。晶状体纤维最显著的变化是肿胀和空泡化。晶状体囊未发现改变。照射后九十天在晶状体后囊下发现晶状体最初可见的混浊，三个月后整个晶状体完全混浊。
