环磷酰胺治疗后迟发型超敏反应部位单核细胞浸润增加。
Increased infiltration by monocytes in delayed type hypersensitivity site following cyclophosphamide treatment.
作者信息
Milon G, Marchal G
出版信息
Immunology. 1978 Dec;35(6):989-95.
Sensitized lymphocytes transferred locally with antigens into footpads of unprinted mice can elicit a delayed-type-hypersensitivity (DTH) reaction. Treatment of recipients with cyclophosphamide (CY) increased the infiltration observed at the DTH site. The enlargement of footpads was detected with low doses of DTH mediating cells as with large ones. An enumeration of circulating monocytes performed on the test days and the preceding days has shown a three to ten fold increase of number of monocytes. During the recovery following CY treatment (20 mg/kg and 200 mg/kg) a rebound effect at level of precursors of monocytes was observed. Thus a dual mechanism is proposed to explain the effect of CY on DTH reaction: a liberation of DTH cells by inhibition of B response as previously described; an increased number of monocytes which can be recruited by DTH-cells in site of antigen injection.
将致敏淋巴细胞与抗原一起局部注射到未致敏小鼠的足垫中，可引发迟发型超敏反应（DTH）。用环磷酰胺（CY）处理受体可增加在DTH部位观察到的浸润。低剂量的DTH介导细胞与高剂量的细胞一样能检测到足垫肿大。在试验当天及之前几天对循环单核细胞进行计数，结果显示单核细胞数量增加了三到十倍。在CY处理（20mg/kg和200mg/kg）后的恢复过程中，观察到单核细胞前体细胞水平的反弹效应。因此，提出了一种双重机制来解释CY对DTH反应的作用：如前所述，通过抑制B反应释放DTH细胞；在抗原注射部位，DTH细胞可募集的单核细胞数量增加。
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