Zebovitz E, Brown A
J Virol. 1968 Nov;2(11):1283-9. doi: 10.21236/ad0844170.
Interference among group A arboviruses is described which does not involve the mediation of interferon. Interference was observed only if the interfering virus had an advantage over the challenge virus, either in time or in multiplicity of infection. Adsorption, penetration, and uncoating of challenge virus did not appear to be inhibited, but the synthesis of infectious viral ribonucleic acid of the challenge virus was significantly retarded. It was shown with temperature-sensitive viruses or mutants that the replication of viral ribonucleic acid by the interfering virus was required to establish interference. A mechanism of interference based on a competition for replication sites or substrates is compared with other possible explanations.
已描述了A组虫媒病毒之间的干扰,这种干扰不涉及干扰素的介导。只有当干扰病毒在感染时间或感染复数方面比攻击病毒具有优势时,才会观察到干扰现象。攻击病毒的吸附、穿透和脱壳似乎未受抑制,但攻击病毒感染性病毒核糖核酸的合成明显延迟。利用温度敏感病毒或突变体表明,干扰病毒对病毒核糖核酸的复制是建立干扰所必需的。将基于复制位点或底物竞争的干扰机制与其他可能的解释进行了比较。