在鸡胚细胞中诱导干扰素所需的病毒事件。
Viral events necessary for the induction of interferon in chick embryo cells.
作者信息
Lockart R Z, Bayliss N L, Toy S T, Yin F H
出版信息
J Virol. 1968 Oct;2(10):962-5. doi: 10.1128/JVI.2.10.962-965.1968.
Abstract
Temperature-sensitive mutants of Sindbis virus were employed to investigate the nature of the viral event(s) which induces chick-embryo cells to produce interferon. Chick embryo cells induced by the parental heat-resistant strain of Sindbis virus produced essentially equal amounts of interferon at 29 and 42 C. An RNA(-) and three RNA(+) strains [temperature-sensitive mutants unable (RNA(-)) and able (RNA(+)) to make ribonucleic acid] produced interferon at 29 C but not at 42 C. It is concluded that viral RNA per se and the replication of viral RNA do not induce interferon production by chick embryo cells.
摘要
辛德毕斯病毒的温度敏感突变体被用于研究诱导鸡胚细胞产生干扰素的病毒事件的本质。由亲代耐热性辛德毕斯病毒株诱导的鸡胚细胞在29℃和42℃时产生的干扰素量基本相等。一种RNA（-）和三种RNA（+）毒株[温度敏感突变体，不能（RNA（-））和能够（RNA（+））产生核糖核酸]在29℃时产生干扰素，但在42℃时不产生。结论是病毒RNA本身和病毒RNA的复制不会诱导鸡胚细胞产生干扰素。
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