[吡拉西坦对乙醇和乙醛作用某些表现的影响]
[Effect of piracetam on some manifestations of the effects of ethanol and acetaldehyde].
作者信息
Vikhliaev Iu I, Artemenko G N, Voronina T A, Ul'ianova O V, Nerobkova L N
出版信息
Farmakol Toksikol. 1979 Jan-Feb;42(1):76-81.
An experimental study of pyracetam (2-pyrrolidonacetamide) showed it capable to mitigate some behavioral and toxic manifestations of the action exerted by alcohol in tests on mice and rats, such as those of the "open field", "conflict situation", "rotating rod" and righting reflex. Pyracetam also attenuated some toxic symptoms of acetaldehyde in mice. It shortened the duration of coma, lessened the intensity of convulsive seizures, but it had no influence on the lethal effect of acetaldehyde. The type of the relation between doses and effects suggests the observed antagonism to be of a nonspecific nature.
对吡拉西坦（2-吡咯烷酮乙酰胺）的一项实验研究表明，在对小鼠和大鼠的测试中，它能够减轻酒精作用所产生的一些行为和毒性表现，例如在“旷场试验”、“冲突情境”、“转棒试验”和翻正反射中的表现。吡拉西坦还减轻了小鼠体内乙醛的一些毒性症状。它缩短了昏迷持续时间，减轻了惊厥发作的强度，但对乙醛的致死作用没有影响。剂量与效应之间的关系类型表明，所观察到的拮抗作用是非特异性的。
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