蛋白聚糖、蛋白酶、趋化作用以及炎症细胞的聚集。
Proteoglycans, proteases, chemotaxis, and aggregation of inflammatory, cells.
作者信息
Lynn W S, Mukherjee C
出版信息
Infect Immun. 1979 Jan;23(1):14-8. doi: 10.1128/iai.23.1.14-18.1979.
Abstract
A trypsin-like protease activity present in rabbit alveolar macrophages was shown to be activated by hyaluronic acid (HA) at 10(-9) M, but not by other proteoglycans. This activation of proteases by HA was accompanied by aggregation of alveolar macrophages and by the release of chemotactic activity. This chemotactic activity was destroyed by proteases and was less active for polymorphonuclear leukocytes than for alveolar macrophages. These effects of HA appear to be sepcific for alveolar macrophages, because no similar effects of HA on human polymorphonuclear leukocytes or lymphocytes could be observed. These observations suggest that HA, which is secreted into airways, plays a specific role in the macrophage-mediated chronic inflammatory processes in the distal lung.
摘要
兔肺泡巨噬细胞中存在的一种类胰蛋白酶活性被证明可被10^(-9) M的透明质酸（HA）激活，但不能被其他蛋白聚糖激活。HA对蛋白酶的这种激活伴随着肺泡巨噬细胞的聚集和趋化活性的释放。这种趋化活性被蛋白酶破坏，对多形核白细胞的活性比对肺泡巨噬细胞的活性低。HA的这些作用似乎对肺泡巨噬细胞具有特异性，因为未观察到HA对人多形核白细胞或淋巴细胞有类似作用。这些观察结果表明，分泌到气道中的HA在远端肺中巨噬细胞介导的慢性炎症过程中起特定作用。
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