尿酸盐晶体诱导趋化因子：分离与部分特性鉴定
Urate crystal-induced chemotactic factor: isolation and partial characterization.
作者信息
Spilbert I, Gallacher A, Mehta J M, Mandell B
出版信息
J Clin Invest. 1976 Oct;58(4):815-9. doi: 10.1172/JCI108533.
Abstract
A factor with chemotactic properties for neutrophils and mononuclear cells was extracted from the lysosomal fraction of both human and rabbit neutrophils that had been allowed to phagocytose monosodium urate crystals. The chemotactic factor was found to be a glycoprotein with a mol wt of 8,400 daltons. The factor is heat labile and has chemotactic activity for human as well as rabbit cells. Preincubation of the cells with the urate induced chemotactic factor or with complement activated plasma prevents the cell from migrating chemotactically when challenged with either factor in the chemotactic chamber. The chemotactic factor induces release of lysosomal enzymes for cytochalasin B treated human neutrophils.
摘要
从已吞噬尿酸钠晶体的人及兔中性粒细胞的溶酶体部分中提取出一种对中性粒细胞和单核细胞具有趋化特性的因子。发现该趋化因子是一种分子量为8400道尔顿的糖蛋白。该因子对热不稳定，对人及兔细胞均有趋化活性。用尿酸诱导的趋化因子或补体激活的血浆对细胞进行预孵育，当在趋化室中用任何一种因子进行刺激时，可防止细胞进行趋化迁移。趋化因子可诱导细胞松弛素B处理的人中性粒细胞释放溶酶体酶。
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