Gayou R M
Plast Reconstr Surg. 1979 May;63(5):700-7. doi: 10.1097/00006534-197905000-00015.
A single blind comparison of capsular tissue obtained from both breasts from 7 patients in whom unilateral contracture had occurred leads to the following conclusions: (1) The presence of droplets (presumed to be silicone, or extractable silicone as identified by IR) in capsular tissue does not correlate with the clinical finding of firmness. (2) Contracted capsules are apt to be significantly more cellular, largely as a result of an increased fibroblast population. (3) The apparent severity of inflammation in a biopsy of a capsule does not correlate with the clinical degree of firmness in the breast. (4) In the 7 cases studied, capsule thickness or vascularity, collagen alignment, staining uptake, presence of foreign bodies, or presence of an inner cell layer of macrophages did not correlate with the clinical finding of firmness.
对7例发生单侧挛缩的患者双侧乳房获取的包膜组织进行单盲比较，得出以下结论：（1）包膜组织中液滴（推测为硅胶，或经红外鉴定为可提取硅胶）的存在与临床硬度表现不相关。（2）挛缩的包膜细胞明显更多，主要是成纤维细胞数量增加所致。（3）包膜活检中炎症的明显严重程度与乳房临床硬度程度不相关。（4）在所研究的7例病例中，包膜厚度或血管分布、胶原排列、染色摄取、异物存在或巨噬细胞内细胞层的存在与临床硬度表现不相关。
